SETDB1 antibody (AA 20-871)

Catalog No. ABIN8036754

The Rabbit Polyclonal anti-SETDB1 antibody is suitable to detect SETDB1 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for SETDB1 antibody (AA 20-871) (ABIN8036754)

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETDB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-SETDB1 Antibody

Binding Specificity: AA 20-871

Purpose: Anti-SETDB1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SETDB1 shares 92.9% amino acid (aa) sequence identity with mouse SETDB1.

Characteristics: Anti-SETDB1 Antibody. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SETDB1 recombinant protein (Position: E20-E871). Human SETDB1 shares 92.9% amino acid (aa) sequence identity with mouse SETDB1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SETDB1

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Alternative Name: SETDB1

Background:

Background: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.

Gene Full Name: SET domain bifurcated histone lysine methyltransferase 1

Molecular Weight: 180 kDa

Gene ID: 9869

UniProt: Q15047