SHBG antibody (AA 30-210) (Fluoro550)

Catalog No. ABIN8036824

The Fluoro550-conjugated Rabbit Polyclonal anti-SHBG antibody (ABIN8036824) specifically detects SHBG in FACS. The antibody is reactive with Human samples.

Quick Overview for SHBG antibody (AA 30-210) (Fluoro550) (ABIN8036824)

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHBG antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-SHBG Antibody (Fluoro550)

Binding Specificity: AA 30-210

Purpose: Anti-Sex Hormone Binding Globulin/SHBG Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SHBG shares 72% amino acid (aa) sequence identity with both mouse,rat SHBG.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SHBG recombinant protein (Position: L30-A210). Human SHBG shares 72% amino acid (aa) sequence identity with both mouse and rat SHBG.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SHBG

Target: SHBG (Sex Hormone Binding Globulin (SHBG))

Alternative Name: SHBG

Background:

Background: Sex hormone-binding globulin (SHBG) is a glycoprotein that binds to the sex hormones,androgen and estrogen. SHBG is produced mostly by the liver and is released into the bloodstream. Other sites that produce SHBG include the brain, uterus, testes, and placenta. SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, andthyroxine cause it to increase. It has been found that the monosaccharides glucose and fructose reduced human SHBG production by hepatocytes, irrespective of the presence of insulin, by downregulation of hepatocyte nuclear factor-4A and replacement of HNF4A by COUP-TFI at a cis-element within the human SHBG promoter, coincident with repression of its transcriptional activity.

Gene Full Name: sex hormone binding globulin

Sequence Similarities: Contains 2 laminin G-like domains.

Gene ID: 6462

UniProt: P04278

Pathways: Hormone Transport