SIRT6 antibody (AA 14-180) (Fluoro488)

Catalog No. ABIN8037829

The Fluoro488-conjugated Rabbit Polyclonal anti-SIRT6 antibody (ABIN8037829) specifically detects SIRT6 in FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for SIRT6 antibody (AA 14-180) (Fluoro488) (ABIN8037829)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT6 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-SIRT6 Antibody (Fluoro488)

Binding Specificity: AA 14-180

Purpose: Anti-SIRT6 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human SIRT6 shares 95% amino acid (aa) sequence identity with mouse SIRT6.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SIRT6 recombinant protein (Position: D14-E180). Human SIRT6 shares 95% amino acid (aa) sequence identity with mouse SIRT6.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background:

Background: SIRT6 is also known as SIR2L6. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.

Gene Full Name: sirtuin 6

Sequence Similarities: Belongs to the sirtuin family. Class IV subfamily.

Gene ID: 51548

UniProt: Q8N6T7