SIRT6 antibody (AA 14-355) (APC)

Catalog No. ABIN8037845

This Rabbit Polyclonal antibody specifically detects SIRT6 in FACS. It exhibits reactivity toward Human.

Quick Overview for SIRT6 antibody (AA 14-355) (APC) (ABIN8037845)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT6 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SIRT6 Antibody (APC)

Binding Specificity: AA 14-355

Purpose: Anti-SIRT6 Antibody APC Conjugated

Predicted Reactivity: Human SIRT6 shares 82.7% amino acid (aa) sequence identity with both mouse SIRT6.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SIRT6 recombinant protein (Position: D14-S355). Human SIRT6 shares 82.7% amino acid (aa) sequence identity with both mouse SIRT6.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background:

Background: Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: sirtuin 6

Gene ID: 51548

UniProt: Q8N6T7