SIVA1 antibody (AA 1-141) (Biotin)

Catalog No. ABIN8037860

This Rabbit Polyclonal antibody specifically detects SIVA1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for SIVA1 antibody (AA 1-141) (Biotin) (ABIN8037860)

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIVA1 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SIVA1 Antibody (Biotin)

Binding Specificity: AA 1-141

Purpose: Anti-SIVA/SIVA1 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SIVA/SIVA1 recombinant protein (Position: M1-T141).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Alternative Name: SIVA1

Background:

Background: Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis.

Gene Full Name: SIVA1 apoptosis inducing factor

Gene ID: 10572

UniProt: O15304

Pathways: Positive Regulation of Endopeptidase Activity