SSH1 antibody (AA 489-921) (Fluoro594)

Catalog No. ABIN8037964

The Fluoro594-conjugated Rabbit Polyclonal anti-SSH1 antibody (ABIN8037964) specifically detects SSH1 in FACS. The antibody is reactive with Human samples.

Quick Overview for SSH1 antibody (AA 489-921) (Fluoro594) (ABIN8037964)

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSH1 antibody is conjugated to Fluoro594

Application: Flow Cytometry (FACS)

Product Details anti-SSH1 Antibody (Fluoro594)

Binding Specificity: AA 489-921

Purpose: Anti-SSH1 Antibody Fluoro594 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human SSH1 shares 66.9% amino acid (aa) sequence identity with mouse SSH1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SSH1 recombinant protein (Position: E489-Y921). Human SSH1 shares 66.9% amino acid (aa) sequence identity with mouse SSH1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SSH1

Target: SSH1 (Slingshot Homolog 1 (SSH1))

Alternative Name: SSH1

Background:

Background: Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene. The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Full Name: slingshot protein phosphatase 1

Gene ID: 54434

UniProt: Q8WYL5

Pathways: CXCR4-mediated Signaling Events