SLC38A9 antibody (AA 33-450) (FITC)

Catalog No. ABIN8040209

This Rabbit Polyclonal antibody specifically detects SLC38A9 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SLC38A9 antibody (AA 33-450) (FITC) (ABIN8040209)

Target: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC38A9 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-SLC38A9 Antibody (FITC)

Binding Specificity: AA 33-450

Purpose: Anti-SLC38A9 Antibody FITC Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SLC38A9 recombinant protein (Position: D33-Q450).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SLC38A9

Target: SLC38A9 (Solute Carrier Family 38, Member 9 (SLC38A9))

Alternative Name: SLC38A9

Background:

Background: Solute carrier family 38 member 9 is a protein that in humans is encoded by the SLC38A9 gene. Sodium-coupled neutral amino acid transporter 9 (SLC38A9) is a lysosomal amino acid transporter, involved in the regulation of mechanistic target of rapamycin complex 1 (mTORC1) activity in response to amino acid levels within the lysosomal lumen. A sodium-couple amino acid transporter at the lysosome, SLC38A9, senses arginine from within the lysosome to convey arginine sufficiency to mTORC1. SLC38A9 forms a complex with other lysosomal resident proteins including the v-ATPase and a pentameric complex called Ragulator. v-ATPase function is necessary for mTORC1 activation, but the molecular mechanism of this regulation is currently unclear2. Ragulator binds strongly to the Rag GTPases and was shown to function as a guanine exchange factor (GEF) for RagA/B. Potentially SLC38A9 and the v-ATPase are able to regulate mTORC1 activity by modulating Ragulator's GEF activity. RagA/B is not the only Rag GTPase that is regulated, but a Folliculin-FNIP2 complex is a GAP for RagC/D. In short, SLC38A9 is a functional component of the lysosomal amino acid sensing machinery involved in the control of mTORC1 activity, that underlies the regulation of the metabolic status and cellular responses to growth factors, energy, glucose and amino acid levels.

Gene Full Name: solute carrier family 38 member 9

Gene ID: 153129

UniProt: Q8NBW4