SPA17 antibody (AA 1-136) (APC)

Catalog No. ABIN8041481

This Rabbit Polyclonal antibody specifically detects SPA17 in FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for SPA17 antibody (AA 1-136) (APC) (ABIN8041481)

Target: SPA17 (Sperm Autoantigenic Protein 17 (SPA17))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPA17 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-SPA17 Antibody (APC)

Binding Specificity: AA 1-136

Purpose: Anti-SPA17 Antibody APC Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human SPA17 shares 75.7% amino acid (aa) sequence identity with mouse SPA17.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SPA17 recombinant protein (Position: M1-K136). Human SPA17 shares 75.7% amino acid (aa) sequence identity with mouse SPA17.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SPA17

Target: SPA17 (Sperm Autoantigenic Protein 17 (SPA17))

Alternative Name: SPA17

Background:

Background: Sperm surface protein Sp17 is a protein that in humans is encoded by the SPA17 gene. This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.

Gene Full Name: sperm autoantigenic protein 17

Gene ID: 53340

UniProt: Q15506