SKAP2 antibody (AA 124-208) (Fluoro488)

Catalog No. ABIN8042130

The Rabbit Polyclonal anti-SKAP2 antibody is suitable to detect SKAP2 in samples from Human and Mouse. It has been validated for FACS.

Quick Overview for SKAP2 antibody (AA 124-208) (Fluoro488) (ABIN8042130)

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKAP2 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-SKAP2 Antibody (Fluoro488)

Binding Specificity: AA 124-208

Purpose: Anti-SKAP2 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SKAP2 recombinant protein (Position: E124-E208).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SKAP2

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Alternative Name: SKAP2

Background:

Background: Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene. The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Full Name: src kinase associated phosphoprotein 2

Gene ID: 8935

UniProt: O75563