SENP6 antibody (AA 135-1086) (HRP)

Catalog No. ABIN8043518

This Rabbit Polyclonal antibody specifically detects SENP6 in ELISA, IHC and WB. It exhibits reactivity toward Human.

Quick Overview for SENP6 antibody (AA 135-1086) (HRP) (ABIN8043518)

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP6 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-SENP6 Antibody (HRP)

Binding Specificity: AA 135-1086

Purpose: Anti-SENP6 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SENP6 recombinant protein (Position: R135-K1086).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SENP6

Target: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Alternative Name: SENP6

Background:

Background: Sentrin-specific protease 6 is an enzyme that in humans is encoded by the SENP6 gene. It is mapped to 6q14.1. Ubiquitin-like molecules (UBLs), such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins. SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates.

Gene Full Name: SUMO specific peptidase 6

Gene ID: 26054

UniProt: Q9GZR1