SYCP3 antibody (AA 18-223) (Fluoro647)

Catalog No. ABIN8044349

This Rabbit Polyclonal antibody specifically detects SYCP3 in FACS. It exhibits reactivity toward Human.

Quick Overview for SYCP3 antibody (AA 18-223) (Fluoro647) (ABIN8044349)

Target: SYCP3 (Synaptonemal Complex Protein 3 (SYCP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYCP3 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-SYCP3 Antibody (Fluoro647)

Binding Specificity: AA 18-223

Purpose: Anti-SCP3/SYCP3 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SCP3 shares 72%,73% amino acid (aa) sequences identity with mouse,rat SCP3,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SCP3 recombinant protein (Position: E18-E223). Human SCP3 shares 72% and 73% amino acid (aa) sequences identity with mouse and rat SCP3, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SYCP3

Target: SYCP3 (Synaptonemal Complex Protein 3 (SYCP3))

Alternative Name: SYCP3

Background:

Background: SYCP3, also known as COR1 or SCP3, is a protein that in humans is encoded by the SYCP3 gene. It is mapped to 12q23.2. This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein by dominant-negative interference. SYCP3 is linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.

Gene Full Name: synaptonemal complex protein 3

Gene ID: 50511

UniProt: Q8IZU3