TNIK antibody (AA 1281-1360) (Biotin)

Catalog No. ABIN754830

This anti-TNIK antibody is a Rabbit Polyclonal antibody detecting TNIK in ELISA, IHC (p) and IHC (fro). Suitable for Mouse and Rat.

Quick Overview for TNIK antibody (AA 1281-1360) (Biotin) (ABIN754830)

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIK antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-TNIK Antibody (Biotin)

Binding Specificity: AA 1281-1360

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TNIK

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TNIK

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Alternative Name: TNIK

Background:

Synonyms: Traf2 and NCK interacting kinase, 1500031A17RIK, 4831440I19RIK, AI451411, C530008O15Rik, C630040K21RIK, KIAA0551, MGC189819, MGC189859, RGD1561817, TNIK, TNIK_HUMAN, TRAF2 and NCK-interacting protein kinase.

Background: TNIK is a MSN protein kinase that interacts with both TNF receptor-associated factor 2 (TRAF2) and the adapter protein NCK. The protein has been shown to activate the c-Jun N-terminal kinase pathway when over expressed in Phoenix-A cells. TNIK has been shown to phosphorylate gelsolin, the principal intracellular and extracellular actin-severing protein, in vitro. This and evidence from mutational studies suggest that TNIK functions in the regulation of the cytoskeleton. Northern analysis indicates TNIK expression in human heart, skeletal muscle, and brain, with lower levels of expression in kidney, liver, lung, and pancreas. ESTs have been isolated from human tissue libraries, including normal amnion, gallbladder and skin.

Gene ID: 23043