TLN1 antibody (AA 1658-1876) (Fluoro550)

Catalog No. ABIN8045324

This Mouse Monoclonal antibody specifically detects TLN1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TLN1 antibody (AA 1658-1876) (Fluoro550) (ABIN8045324)

Target: TLN1 (Talin 1 (TLN1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TLN1 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Clone: 2G10D2

Product Details anti-TLN1 Antibody (Fluoro550)

Binding Specificity: AA 1658-1876

Purpose: Anti-Talin 1/TLN1 Antibody (monoclonal, 2G10D2) Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Talin 1/TLN1 recombinant protein (Position: Q1658-N1876).

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TLN1

Target: TLN1 (Talin 1 (TLN1))

Alternative Name: TLN1

Background:

Background: Talin-1 is a protein that in humans is encoded by the TLN1 gene. This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

Gene Full Name: talin 1

Gene ID: 7094

UniProt: Q9Y490

Pathways: Cell-Cell Junction Organization, ER-Nucleus Signaling, Maintenance of Protein Location