TTC39B antibody (AA 129-682) (Fluoro647)

Catalog No. ABIN8045981

This Rabbit Polyclonal antibody specifically detects TTC39B in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TTC39B antibody (AA 129-682) (Fluoro647) (ABIN8045981)

Target: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTC39B antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-TTC39B Antibody (Fluoro647)

Binding Specificity: AA 129-682

Purpose: Anti-TTC39B Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TTC39B recombinant protein (Position: K129-D682).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TTC39B

Target: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Alternative Name: TTC39B

Background:

Background: Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B protein contains two TPR repeats (aa 39 3-426 and 626 -659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LX R protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficiency mice display higher levels of HDL and Apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis.However it does not affect glucose tolerance or hepatic gluconeogenesis.

Gene Full Name: tetratricopeptide repeat domain 39B

Gene ID: 158219

UniProt: Q5VTQ0