TTC39B antibody (AA 129-682)

Catalog No. ABIN8045982

The Rabbit Polyclonal anti-TTC39B antibody is suitable to detect TTC39B in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for TTC39B antibody (AA 129-682) (ABIN8045982)

Target: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTC39B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-TTC39B Antibody

Binding Specificity: AA 129-682

Purpose: Anti-TTC39B Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-TTC39B Antibody. Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TTC39B recombinant protein (Position: K129-D682).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TTC39B

Target: TTC39B (Tetratricopeptide Repeat Domain 39B (TTC39B))

Alternative Name: TTC39B

Background:

Background: Tetratricopeptide repeat protein 39B is a protein that in humans is encoded by the TTC39B gene. TTC39B protein contains two TPR repeats (aa 39 3-426 and 626 -659). TCC39B protein is the product of a high density lipoprotein (HDL) gene that promotes the ubiquitination and degradation of liver X receptor (LXR). TTC39B null or deficient mice challenged with high fat/cholesterol/bile salt diet exhibit increased LX R protein and target gene expression. TTC39B deficiency is reported to stabilize LXR by reducing its polyubiquitination and proteasomal degradation. Hence it reduces the incidence of atherosclerosis and steatohepatitis. TTC39B deficiency mice display higher levels of HDL and Apoplipoprotein A-1 and lower levels of hepatic triglyceride synthesis.However it does not affect glucose tolerance or hepatic gluconeogenesis.

Gene Full Name: tetratricopeptide repeat domain 39B

Molecular Weight: 70 kDa

Gene ID: 158219

UniProt: Q5VTQ0