MAFA antibody (Middle Region) (Fluoro488)

Catalog No. ABIN8047976

This Rabbit Polyclonal antibody specifically detects MAFA in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for MAFA antibody (Middle Region) (Fluoro488) (ABIN8047976)

Target: MAFA (Transcription Factor MafA (MAFA))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAFA antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-MAFA Antibody (Fluoro488)

Binding Specificity: Middle Region

Purpose: Anti-Transcription factor MafA MAFA Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human MAFA, identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for MAFA

Target: MAFA (Transcription Factor MafA (MAFA))

Alternative Name: MAFA

Background:

Background: MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells. It is located in 8q24.3. The intracellular domain of MAFA contains a single immunoreceptor tyrosine-based inhibitory motif (ITIM), which classifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the antigen-induced (i.e. Fc epsilon RI-induced) secretion ofinflammatory mediators.

Gene Full Name: MAF bZIP transcription factor A

Sequence Similarities: Belongs to the bZIP family. Maf subfamily.

Gene ID: 389692

UniProt: Q8NHW3

Pathways: Hormone Transport