Transgelin antibody (AA 15-170) (PE)

Catalog No. ABIN8048214

The Rabbit Polyclonal anti-Transgelin antibody is suitable to detect Transgelin in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for Transgelin antibody (AA 15-170) (PE) (ABIN8048214)

Target: Transgelin (TAGLN)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transgelin antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Transgelin Antibody (PE)

Binding Specificity: AA 15-170

Purpose: Anti-TAGLN/Transgelin Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TAGLN/Transgelin recombinant protein (Position: Q15-E170).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Transgelin

Target: Transgelin (TAGLN)

Alternative Name: TAGLN

Background:

Background: Transgelin, also known as SM22 alpha, is a protein that in humans is encoded by the TAGLN gene. This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

Gene Full Name: transgelin

Gene ID: 6876

UniProt: Q01995