TMC6 antibody (AA 1-772) (Fluoro488)

Catalog No. ABIN8048879

This Rabbit Polyclonal antibody specifically detects TMC6 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TMC6 antibody (AA 1-772) (Fluoro488) (ABIN8048879)

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMC6 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-TMC6 Antibody (Fluoro488)

Binding Specificity: AA 1-772

Purpose: Anti-TMC6 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human TMC6 shares 76.7% amino acid (aa) sequence identity with mouse TMC6.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human TMC6 recombinant protein (Position: M1-H772). Human TMC6 shares 76.7% amino acid (aa) sequence identity with mouse TMC6.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for TMC6

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Alternative Name: TMC6

Background:

Background: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs.

Gene Full Name: transmembrane channel like 6

Gene ID: 11322

UniProt: Q7Z403