proBNP antibody (AA 21-121) (HRP)

Catalog No. ABIN755521

Product Details anti-proBNP Antibody (HRP)

Target: proBNP (Pro-Brain Natriuretic Peptide (proBNP))

Binding Specificity: AA 21-121

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This proBNP antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse proBNP

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for proBNP

Target: proBNP (Pro-Brain Natriuretic Peptide (proBNP))

Alternative Name: proBNP (proBNP Products)

Synonyms: BNP antibody, natriuretic peptide B antibody, NPPB antibody

Background:

Synonyms: BNP 32, BNP1-28, BNP1-29, BNP1-30, BNP1-32, BNP2-31, BNP3-29, BNP3-30, BNP3-32, BNP4-27, BNP4-29, BNP4-30, BNP4-31, BNP4-32, BNP5-29, BNP5-31, BNP5-32, Brain natriuretic peptide 32, Brain type natriuretic peptide, Gamma brain natriuretic peptide, Natriuretic peptide B, Natriuretic peptide brain type, Natriuretic peptide precursor B, natriuretic peptide, brain type, ANFB_MOUSE, Natriuretic peptides B, natriuretic protein, NPPB, NPPB protein.

Background: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.

Gene ID: 18158