Utrophin antibody (AA 1211-2294)

Catalog No. ABIN8052949

The Rabbit Polyclonal anti-Utrophin antibody (ABIN8052949) specifically detects Utrophin in WB, ELISA, ICC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for Utrophin antibody (AA 1211-2294) (ABIN8052949)

Target: Utrophin (UTRN)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Utrophin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Grade: Carrier-free

Product Details anti-Utrophin Antibody

Binding Specificity: AA 1211-2294

Purpose: Anti-Utrophin/UTRN Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Utrophin/UTRN Antibody. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Utrophin

Target: Utrophin (UTRN)

Alternative Name: UTRN

Background:

Background: Utrophin is a protein that in humans is encoded by the UTRN gene. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described, however, the full-length nature of these variants has not yet been determined.

Gene Full Name: utrophin

Molecular Weight: 394 kDa

Gene ID: 7402

UniProt: P46939

Pathways: Skeletal Muscle Fiber Development