VNN1 antibody (AA 22-192) (Fluoro647)

Catalog No. ABIN8053344

The Rabbit Polyclonal anti-VNN1 antibody is suitable to detect VNN1 in samples from Human. It has been validated for FACS.

Quick Overview for VNN1 antibody (AA 22-192) (Fluoro647) (ABIN8053344)

Target: VNN1 (Vanin 1 (VNN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VNN1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-VNN1 Antibody (Fluoro647)

Binding Specificity: AA 22-192

Purpose: Anti-VNN1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: coli-derived human VNN1 recombinant protein (Position: Q22-K192). Human VNN1 shares 82.2% amino acid (aa) sequence identity with mouse VNN1.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human VNN1 recombinant protein (Position: Q22-K192). Human VNN1 shares 82.2% amino acid (aa) sequence identity with mouse VNN1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for VNN1

Target: VNN1 (Vanin 1 (VNN1))

Alternative Name: VNN1

Background:

Background: Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene. This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.

Gene Full Name: vanin 1

Gene ID: 8876

UniProt: O95497

Pathways: Negative Regulation of intrinsic apoptotic Signaling