PROC antibody (AA 200-461) (HRP)

Catalog No. ABIN8053759

The HRP-conjugated Rabbit Polyclonal anti-PROC antibody (ABIN8053759) specifically detects PROC in WB, IHC and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PROC antibody (AA 200-461) (HRP) (ABIN8053759)

Target: PROC (Vitamin K-dependent protein C (PROC))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PROC antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-PROC Antibody (HRP)

Binding Specificity: AA 200-461

Purpose: Anti-Protein C/PROC Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Protein C recombinant protein (Position: D200-P461).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Alternative Name: PROC

Background:

Background: Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Gene Full Name: protein C, inactivator of coagulation factors Va and VIIIa

Gene ID: 5624

UniProt: P04070