MORG1 antibody (N-Term) (HRP)

Catalog No. ABIN8054145

The Rabbit Polyclonal anti-MORG1 antibody is suitable to detect MORG1 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for MORG1 antibody (N-Term) (HRP) (ABIN8054145)

Target: MORG1 (wdr83) (WD Repeat Domain 83 (wdr83))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MORG1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-MORG1 Antibody (HRP)

Binding Specificity: N-Term

Purpose: Anti-Morg1/WDR83 Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse,rat sequences.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Morg1, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MORG1

Target: MORG1 (wdr83) (WD Repeat Domain 83 (wdr83))

Alternative Name: WDR83

Background:

Background: MORG1 (mitogen-activated protein kinase organizer 1), a member of the WD-40 protein family that was isolated as a binding partner of the extracellular signal-regulated kinase (ERK) pathway scaffold protein MP1. MORG1 specifically associates with several components of the ERK pathway, including MP1, Raf-1, MEK, and ERK, and stabilizes their assembly into an oligomeric complex. MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor. Suppression of MORG1 by short interfering RNA leads to a marked reduction in ERK activity when cells are stimulated with serum. MORG1 is a component of a modular scaffold system that participates in the regulation of agonist-specific ERK signaling.

Gene Full Name: WD repeat domain 83

Sequence Similarities: Belongs to the WD repeat MORG1 family.

Gene ID: 84292

UniProt: Q9BRX9