ZBTB48 antibody (AA 1-623) (HRP)

Catalog No. ABIN8055114

The Rabbit Polyclonal anti-ZBTB48 antibody is suitable to detect ZBTB48 in samples from Human. It has been validated for WB, ELISA and IHC.

Quick Overview for ZBTB48 antibody (AA 1-623) (HRP) (ABIN8055114)

Target: ZBTB48 (Zinc Finger and BTB Domain Containing 48 (ZBTB48))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB48 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ZBTB48 Antibody (HRP)

Binding Specificity: AA 1-623

Purpose: Anti-ZBTB48 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ZBTB48 recombinant protein (Position: M1-M623).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ZBTB48

Target: ZBTB48 (Zinc Finger and BTB Domain Containing 48 (ZBTB48))

Alternative Name: ZBTB48

Background:

Background: Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that ly binds to the double-stranded repeat sequence of telomeres. In humans it is encoded by the ZBTB48 gene. ZBTB48, also named as TZAP and HKR3, is a 688 amino acid protein, which contains 1 BTB (POZ) domain and 11 C2H2-type zinc fingers and belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB48 is detected in adrenal gland and neuroblastoma. ZBTB48 binds to and regulates the J and/or S elements in MHC II promoter. Zinc finger and BTB domain containing 48 (ZBTB48), also known as telomeric zinc-finger associated protein (TZAP), is a protein that triggers the trimming of telomeres in the absence of shelterin. ZBTB48, is a relatively uncharacterized POK family protein with a POZ-domain and 11 zinc finger domains. ZBTB48, is ubiquitously expressed in human tissues. The ZBTB48 gene is mapped to human chromosome 1p36, which is commonly rearranged (leiomyoma and leukemias) or deleted in various cancers (neuroblastoma, melanoma, Merkel cell carcinomas, pheochromocytoma and breast and colon carcinomas. A correlation between deletions or rearrangements of HKR3 and human cancer suggest a role for ZBTB48 as a potential tumor suppressor.

Gene Full Name: zinc finger and BTB domain containing 48

Gene ID: 3104

UniProt: P10074