PATZ1 antibody (AA 145-680) (HRP)

Catalog No. ABIN8055224

This Rabbit Polyclonal antibody specifically detects PATZ1 in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for PATZ1 antibody (AA 145-680) (HRP) (ABIN8055224)

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PATZ1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-PATZ1 Antibody (HRP)

Binding Specificity: AA 145-680

Purpose: Anti-PATZ1 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human PATZ1 shares 98.9% amino acid (aa) sequence identity with mouse PATZ1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human PATZ1 recombinant protein (Position: M145-Q680). Human PATZ1 shares 98.9% amino acid (aa) sequence identity with mouse PATZ1.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PATZ1

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Alternative Name: PATZ1

Background:

Background: POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

Gene Full Name: POZ/BTB and AT hook containing zinc finger 1

Gene ID: 23598

UniProt: Q9HBE1