COL3 antibody

Catalog No. ABIN8065429

The Mouse Monoclonal anti-COL3 antibody (Clone 1E7-D7-Col3) (ABIN8065429) specifically detects COL3 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for COL3 antibody (ABIN8065429)

Target: COL3 (Collagen, Type III (COL3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This COL3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Grade: Carrier-free

Clone: 1E7-D7-Col3

Product Details anti-COL3 Antibody

Purpose: Anti-Type III Collagen Antibody

Specificity: CSI 007-01 is highly specific for type III collagen. It has been shown to have no cross-ractivity with type I and V collagens by ELISA and immunoblotting. There is no evidence for cross-reactivity with other connective tissue proteins (laminin, fibronectin, elastin). Epitope is located approximately 100nm from the N-terminal of the molecule.

Predicted Reactivity: Canine,Human,Kangaroo,and Rat

Purification: Protein A or Protein G purified

Immunogen: Acid-digested pepsin soluble human type III collagen

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for COL3

Target: COL3 (Collagen, Type III (COL3))

Alternative Name: Type III Collagen

Background: COL3A1, EDS4A, EDSVASC, PMGEDSV, collagen alpha-1(III) chain, Ehlers-Danlos syndrome type IV, autosomal dominant, alpha-1 type III collagen, alpha1 (III) collagen, collagen, fetal, collagen, type III, alpha 1,Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.,COL3A1,Type III collagen is present in the walls of arteries, intestines and the uterus, where it strenghtens the connective tissue. Patients with defects in the type III collagen (ex. Ehlers-Danlos syndrome) are at risk of rupture of major arteries or the intestine.

Molecular Weight: 139 kDa

Gene ID: 1281

UniProt: P02461