Exendin 4 antibody

Catalog No. ABIN8065455

The Mouse Monoclonal anti-Exendin 4 antibody is suitable to detect Exendin 4 in samples from Gila monster. It has been validated for ELISA.

Quick Overview for Exendin 4 antibody (ABIN8065455)

Target: Exendin 4

Reactivity: Gila monster

Host: Mouse

Clonality: Monoclonal

Conjugate: This Exendin 4 antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: 2E1

Product Details anti-Exendin 4 Antibody

Purpose: Anti-Exendin-4 Antibody

Specificity: Specific for exendin-4. No cross-reactivity with GLP-1, GLP-2 (human) or glucagon coated on ELISA wells. The epitope is in the 9-39 region of the peptide, and the antibody cross-reacts strongly with exendin (9-39) amide.

Predicted Reactivity: Gila monster Heloderma suspectum

Purification: Protein A or Protein G purified

Immunogen: Synthetic exendin-4

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for Exendin 4

Target: Exendin 4

Alternative Name: Exendin-4

Background: Exenatide,Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.,N/A,Exendin-4 is a 39 amino acid peptide found in venom from the Gila monster Heloderma suspectum. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. Exendin-4 is a potent agonist of the GLP-1 receptor and hence a potent stimulator of insulin secretion.

Molecular Weight: 4.2 kDa

UniProt: P26349