FCN3 antibody

Catalog No. ABIN8065465

The Mouse Monoclonal anti-FCN3 antibody (Clone FCN334) (ABIN8065465) specifically detects FCN3 in ELISA and IP. The antibody is reactive with Human samples.

Quick Overview for FCN3 antibody (ABIN8065465)

Target: FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FCN3 antibody is un-conjugated

Application: ELISA, Immunoprecipitation (IP)

Grade: Carrier-free

Clone: FCN334

Product Details anti-FCN3 Antibody

Purpose: Anti-H-Ficolin Antibody

Specificity: ABIN8065465 reacts specifically with H-ficolin. No cross-reaction has been observed with L- or M-ficolin.

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Recombinant human H-ficolin

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for FCN3

Target: FCN3 (Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3))

Alternative Name: H-Ficolin

Background: FCN3, FCNH, HAKA1, ficolin-3, H-ficolin, collagen/fibrinogen domain-containing lectin 3 p35, collagen/fibrinogen domain-containing protein 3, ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen),Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11907111, PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed:17215869). {ECO:0000269|PubMed:11907111, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:26133042}.,FCN3,H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35 kDa protein chains associated in triplet subunits which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region.

Molecular Weight: 35 kDa

Gene ID: 8547

UniProt: O75636

Pathways: Complement System