OXM antibody

Catalog No. ABIN8065512

The Mouse Monoclonal anti-OXM antibody is suitable to detect OXM in samples from Human. It has been validated for ELISA.

Quick Overview for OXM antibody (ABIN8065512)

Target: OXM (Oxyntomodulin (OXM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OXM antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: 2E1

Product Details anti-OXM Antibody

Purpose: Anti-Oxyntomodulin Antibody

Specificity: ABS 059-20 is specific for human oxyntomodulin. Cross-reacts fully with glucagon. ABS 059-20 has a different epitope specificity than ABS 064-46 and ABS 064-23.

Predicted Reactivity: Human,Mouse,and Rat

Purification: Protein A or Protein G purified

Immunogen: Synthetic full length oxyntomodulin coupled to carrier.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.14 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 12 months

Target Details for OXM

Target: OXM (Oxyntomodulin (OXM))

Alternative Name: Oxyntomodulin

Background: GCG, GLP-1, GLP1, GLP2, GRPP, pro-glucagon, glicentin-related polypeptide, glucagon-like peptide 1, glucagon-like peptide 2, incretin, preproglucagon,Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release (PubMed:22037645, PubMed:40446798). Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels (PubMed:10605628, PubMed:14719035, PubMed:12554744). May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin (PubMed:10605628, PubMed:14719035, PubMed:12554744). Has growth-promoting activities on intestinal epithelium (PubMed:10605628, PubMed:14719035, PubMed:12554744). May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion (PubMed:10605628, PubMed:14719035, PubMed:12554744). Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation (PubMed:10605628, PubMed:14719035, PubMed:12554744). Inhibits beta cell apoptosis (PubMed:10605628, PubMed:14719035, PubMed:12554744).,GCG,Oxyntomodulin is a peptide hormone of 37 amino-acid residues (29-amino acid sequence of glucagon, with an 8-amino acid carboxy-terminal extension) produced by the L cells of the gut. It modulates gastric acid secretion from the oxyntic cells of the stomach, inhibits appetite and has glucose lowering effects. Oxyntomodulin is produced by cell-type-specific processing of proglucagon that forms as well glicentin, GLP-1 and GLP-2 in the L cells of the intestinal mucosa.

Molecular Weight: 20 kDa

Gene ID: 2641

UniProt: P01275