Peptide Histidine-Methionine antibody

Catalog No. ABIN8065516

The Mouse Monoclonal anti-Peptide Histidine-Methionine antibody (Clone 3) (ABIN8065516) specifically detects Peptide Histidine-Methionine in ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for Peptide Histidine-Methionine antibody (ABIN8065516)

Target: Peptide Histidine-Methionine (PHM)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Peptide Histidine-Methionine antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: 3

Product Details anti-Peptide Histidine-Methionine Antibody

Purpose: Anti-Peptide Histidine Methionine Antibody

Specificity: ABS 020-03 binds human PHM and cross-reacts with PACAP (approximately 12 % , incomplete, non-parallel inhibition). ABS 020-03 does not cross-react with GLP-1, GLP-2, VIP or glucagon.

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Synthetic human peptide histidine-methionine

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for Peptide Histidine-Methionine

Target: Peptide Histidine-Methionine (PHM)

Alternative Name: Peptide Histidine Methionine

Background: VIP, PHM27, VIP peptides, prepro-VIP,[Vasoactive intestinal peptide]: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2) (PubMed:1318039, PubMed:36385145, PubMed:8933357). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (PubMed:3456568). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (PubMed:15013843). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3456568, ECO:0000269|PubMed:36385145, ECO:0000269|PubMed:8933357}., [Intestinal peptide PHM-27]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (PubMed:15013843). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}., [Intestinal peptide PHV-42]: Bioactive forms that cause vasodilation (PubMed:15013843, PubMed:3654650). {ECO:0000269|PubMed:15013843, ECO:0000269|PubMed:3654650}.,VIP,Human peptide histidine-methionine (PHM) is a 27 amino acid peptide belonging to the glucagon-secretin family of peptide hormones. PHM is produced from the same prohormone as VIP, with which it shows considerable sequence homology. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine. In some situations the effect of the peptides is to reinforce and prolong the effects of neurotransmitter release. Like VIP, PHM is a vasodilator and stimulator of intestinal fluid secretion. High plasma levels of PHM are diagnostic of the corresponding peptide-producing tumor (VIPoma), associated with the watery diarrhea-hypokalemia-achlorhydria syndrome.

Molecular Weight: 3 kDa

Gene ID: 7432

UniProt: P01282