PAEP antibody

Catalog No. ABIN8065526

This Mouse Monoclonal antibody specifically detects PAEP in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for PAEP antibody (ABIN8065526)

Target: PAEP (Progestagen-Associated Endometrial Protein (PAEP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAEP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: 13

Product Details anti-PAEP Antibody

Purpose: Anti-Placental Protein 14 Antibody

Specificity: BTE 001-13 is specific for human PP14. Differs from BTE 001-16

Predicted Reactivity: Human

Purification: Protein A or Protein G purified

Immunogen: Placental protein 14 (glycodelin A) purified from second trimester amniotic fluid

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for PAEP

Target: PAEP (Progestagen-Associated Endometrial Protein (PAEP))

Alternative Name: Placental Protein 14

Background: PAEP, GD, GdA, GdF, GdS, PAEG, PEP, PP14, ZIF-1, glycodelin, PEG, PP14 protein (placental protein 14), alpha uterine protein, glycodelin-A, glycodelin-F, glycodelin-S, placental protein 14, pregnancy-associated endometrial alpha-2 globulin, progestagen-associated endometrial protein (placental protein 14, pregnancy-associated endometrial a, progesterone-associated endometrial protein, zona-binding inhibitory factor-1,Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:7531163, PubMed:9918684). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260). Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671). Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155). {ECO:0000269|PubMed:12672671, ECO:0000269|PubMed:15883155, ECO:0000269|PubMed:17192260, ECO:0000269|PubMed:7531163, ECO:0000269|PubMed:9918684}.,PAEP,Human placental protein 14 (PP14, also known as glycodelin and progesterone-associated endometrial protein) is a protein of the lipocalin structural superfamily. PP14 is the most abundant product of the secretory endometrium, and has been proposed as a biochemical marker of endometrial function in women undergoing in vitro fertilization treatment (1).

Molecular Weight: 20 kDa

Gene ID: 5047

UniProt: P09466