CGRP antibody

Catalog No. ABIN8065540

The Mouse Monoclonal anti-CGRP antibody (Clone 4) (ABIN8065540) specifically detects CGRP in ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for CGRP antibody (ABIN8065540)

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CGRP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: 4

Product Details anti-CGRP Antibody

Purpose: Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody

Specificity: ABIN8065541 binds human α-CGRP. Based on inhibition ELISA, ABIN8065541 cross-reacts up to 12 % with human β-CGRP and human amylin, while there is little (<4 %) cross-reaction with rat α-CGRP. The epitope lies within residues 19-37 of human α-CGRP.

Predicted Reactivity: Human,Rat

Purification: Protein A or Protein G purified

Immunogen: Synthetic human alpha-CGRP

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C without exposure to light

Expiry Date: 24 months

Target Details for CGRP

Target: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Alternative Name: Alpha-Calcitonin Gene-Related Peptide

Background: CALCA, CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCT, calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin,CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:3492492, ECO:0000269|PubMed:38603770, ECO:0000269|PubMed:9620797}.,CALCA,Calcitonin gene-related peptide is a 37 amino acid vasoactive neuropeptide (MW 3789) widely expressed throughout the central and peripheral nervous system. CGRP has potent vasodilatory effects probably serving as a regulator of regional blood flow, in addition to a variety of other cellular effects.

Molecular Weight: 11 kDa (pro-CGRP), 5 kDa (active)

Gene ID: 796

UniProt: P06881

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour