Recombinant CEACAM6 antibody

Catalog No. ABIN8093034

The Rabbit Monoclonal anti-CEACAM6 antibody (Clone CEACAM6-13371R) (ABIN8093034) specifically detects CEACAM6 in WB, IHC and FACS. The antibody is reactive with Human samples.

Quick Overview for Recombinant CEACAM6 antibody (ABIN8093034)

Target: CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CEACAM6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: CEACAM6-13371R

Product Details anti-CEACAM6 Antibody

Purpose: CEACAM6 Antibody / Carcinoembryonic antigen-related cell adhesion molecule 6

Immunogen: Recombinant CEACAM6 protein was used as the immunogen for the CEACAM6/Carcinoembryonic antigen-related cell adhesion molecule 6 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: 1. Optimal dilution of the CEACAM6/Carcinoembryonic antigen-related cell adhesion molecule 6 antibody should be determined by the researcher.

2. This CEACAM6/Carcinoembryonic antigen-related cell adhesion molecule 6 antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: CEACAM6/Carcinoembryonic antigen-related cell adhesion molecule 6 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for CEACAM6

Target: CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (CEACAM6))

Alternative Name: CEACAM6

Background: CEACAM6 antibody (clone CEACAM6/13371R) targets Carcinoembryonic Antigen Related Cell Adhesion Molecule 6, a glycosylphosphatidylinositol-anchored cell surface glycoprotein encoded by the human CEACAM6 gene. CEACAM6, also widely referred to as CD66c in immunology literature, is a member of the carcinoembryonic antigen related cell adhesion molecule family involved in intercellular adhesion and immune regulation. CEACAM6 antibody is commonly used in studies of epithelial biology, tumor progression, and inflammatory signaling because CEACAM6 expression is frequently elevated in multiple carcinomas.

CEACAM6 is localized to the plasma membrane via a GPI anchor and mediates homophilic and heterophilic cell-cell interactions. In normal tissues, CEACAM6 is expressed on granulocytes and certain epithelial cells, including those of the gastrointestinal and respiratory tracts. Overexpression of CEACAM6 has been reported in colorectal, pancreatic, gastric, breast, and lung cancers, where it has been associated with tumor cell adhesion, invasion, and resistance to apoptosis. CEACAM6 antibody clone CEACAM6/13371R supports detection of CEACAM6 expression in epithelial tumors and immune cell populations in research applications.

Functionally, CEACAM6 participates in signaling pathways that influence cell survival, proliferation, and metastatic potential. Increased CEACAM6 expression has been linked to enhanced tumor cell motility and reduced anoikis sensitivity, contributing to cancer progression. Because of its cell surface localization and tumor-associated overexpression, CEACAM6 antibody is frequently applied in cancer biology and translational oncology research.

Structurally, CEACAM6 contains immunoglobulin-like extracellular domains characteristic of the CEACAM family and lacks a transmembrane domain due to its GPI anchorage. A CEACAM6 antibody such as clone CEACAM6/13371R is suitable for detecting CEACAM6 expression in epithelial tissues and tumor specimens in research settings.

UniProt: P40199