Recombinant CD200R1 antibody (AA 50-250)

Catalog No. ABIN8093053

This Rabbit Monoclonal antibody specifically detects CD200R1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant CD200R1 antibody (AA 50-250) (ABIN8093053)

Target: CD200R1 (CD200 Receptor 1 (CD200R1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD200R1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: CD200R1-9919R

Product Details anti-CD200R1 Antibody

Binding Specificity: AA 50-250

Purpose: CD200R1 Antibody / OX-2 receptor (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 50-250) of human CD200R1 protein (exact sequence is proprietary) was used as the immunogen for the OX2R/OX-2 receptor antibody.

Isotype: IgG, kappa

Application Details

Application Notes: 1. Optimal dilution of the OX2R/OX-2 receptor antibody should be determined by the researcher.

2. This OX2R/OX-2 receptor antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: OX2R/OX-2 receptor antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for CD200R1

Target: CD200R1 (CD200 Receptor 1 (CD200R1))

Alternative Name: CD200R1

Background: OX2R antibody targets OX-2 receptor, also known as CD200 receptor 1 (CD200R1), an immunoregulatory cell surface receptor that plays a key role in controlling immune activation and maintaining peripheral tolerance. OX-2 receptor is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily and is predominantly expressed on myeloid lineage cells, including macrophages, dendritic cells, and certain lymphocyte subsets. The receptor interacts with its ligand CD200 (OX-2), delivering inhibitory signals that dampen inflammatory and immune responses.

OX-2 receptor functions as an immune checkpoint molecule by suppressing excessive activation of innate and adaptive immune cells. Engagement of OX2R by CD200 leads to recruitment of intracellular adaptor proteins and downstream signaling pathways that limit pro-inflammatory cytokine production and cellular activation. This regulatory axis is essential for immune homeostasis, helping prevent tissue damage during immune responses while supporting tolerance to self-antigens.

OX2R antibody, also referred to as OX-2 receptor antibody and CD200 receptor 1 antibody in the literature, is commonly used in research settings to examine immune inhibitory pathways and cell surface receptor expression. OX-2 receptor has been studied extensively in the context of immune regulation, transplantation biology, tumor immune evasion, and neuroinflammation. Dysregulation of CD200-CD200R signaling has been associated with altered immune surveillance in cancer and chronic inflammatory conditions, highlighting its relevance in immunology research.

At the cellular level, OX-2 receptor is localized primarily to the plasma membrane, consistent with its role as a ligand-binding inhibitory receptor. Expression patterns vary depending on tissue type and immune cell activation state, with higher levels often observed in immune-rich environments. The receptor is encoded by the CD200R1 gene and is sometimes abbreviated as OX2R in immunology-focused studies and antibody catalogs. Clone CD200R1/9919R is designed to recognize OX-2 receptor for research applications requiring consistent target detection. In studies utilizing OX2R antibody, clone CD200R1/9919R has been incorporated as a molecular tool to support investigations into immune checkpoint signaling and receptor expression profiling.

OX-2 receptor is also referred to by several alternative names, including CD200R, CD200R1, and OX2R, reflecting its long-standing presence in immunological research. Because of its inhibitory function, OX2R antibody is frequently included in studies focused on immune modulation, myeloid cell biology, and mechanisms of immune suppression. Clone CD200R1/9919R provides a defined reagent option for researchers examining OX-2 receptor expression within these biological contexts.

UniProt: Q8TD46