CXCR5 antibody

Catalog No. ABIN8093080

This Mouse Monoclonal antibody specifically detects CXCR5 in IHC. It exhibits reactivity toward Human.

Quick Overview for CXCR5 antibody (ABIN8093080)

Target: CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CXCR5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: CXCR5-13100

Product Details anti-CXCR5 Antibody

Purpose: CXCR5 Antibody / C-X-C motif chemokine receptor 5 (azide and preservative free)

Immunogen: A recombinant fragment of human CXCR5 protein (exact sequence is proprietary) was used as the immunogen for the Burkitt Lymphoma Receptor 1/CXCR5 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Burkitt Lymphoma Receptor 1/CXCR5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Burkitt Lymphoma Receptor 1/CXCR5 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for CXCR5

Target: CXCR5 (Chemokine (C-X-C Motif) Receptor 5 (CXCR5))

Alternative Name: CXCR5

Background: Burkitt Lymphoma Receptor 1 antibody, also known as CXCR5 antibody, recognizes C-X-C motif chemokine receptor 5, a seven-transmembrane G protein-coupled receptor encoded by the CXCR5 gene and commonly referred to as CD185. Burkitt Lymphoma Receptor 1 is primarily localized to the plasma membrane of B lymphocytes and subsets of T cells, particularly follicular helper T cells, where it regulates chemokine-directed cell migration. As a member of the CXC chemokine receptor family, CXCR5 binds the ligand CXCL13 and plays a central role in lymphoid follicle organization and germinal center formation.

Burkitt Lymphoma Receptor 1 antibody detects a multi-pass transmembrane receptor composed of seven alpha-helical membrane-spanning domains, extracellular regions responsible for ligand binding, and intracellular domains that couple to heterotrimeric G proteins. Upon binding CXCL13, CXCR5 activates downstream signaling pathways that promote cytoskeletal rearrangement and directed chemotaxis. Through these mechanisms, CD185 directs B cells and T follicular helper cells into B cell follicles within secondary lymphoid tissues, supporting adaptive immune responses and antibody affinity maturation.

Functionally, CXCR5 is essential for humoral immunity and proper germinal center architecture. Expression of Burkitt Lymphoma Receptor 1 defines follicular B cells and T follicular helper cells and is widely used as a marker in immunophenotyping studies. Dysregulated CXCR5 signaling has been implicated in autoimmune diseases, chronic inflammatory disorders, and lymphoid malignancies. In certain B cell lymphomas, altered CXCR5 expression may influence tumor cell localization and interaction with the lymphoid microenvironment.

The CXCR5 gene is located on chromosome 11 and is transcriptionally regulated during lymphocyte activation and differentiation. Because Burkitt Lymphoma Receptor 1 expression is largely restricted to defined immune cell subsets, detection of this receptor provides insight into lymphocyte trafficking, germinal center dynamics, and immune cell compartmentalization within tissues.

The Burkitt Lymphoma Receptor 1 antibody (clone CXCR5/13100) is suitable for detecting CXCR5 protein expression in research applications. This CXCR5 antibody supports investigation of B cell biology, T follicular helper cell function, lymphoid tissue organization, and immune-mediated disease mechanisms.

UniProt: P32302