Recombinant CLPS antibody (AA 1-112)

Catalog No. ABIN8093095

This Rabbit Monoclonal antibody specifically detects CLPS in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Guinea Pig and Hamster.

Quick Overview for Recombinant CLPS antibody (AA 1-112) (ABIN8093095)

Target: CLPS (Colipase, Pancreatic (CLPS))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat, Guinea Pig, Hamster

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CLPS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CLPS-12806R

Product Details anti-CLPS Antibody

Binding Specificity: AA 1-112

Purpose: CLPS Antibody / Colipase

Immunogen: A recombinant fragment (around amino acids 1-112) of human CLPS protein (exact sequence is proprietary) was used as the immunogen for the CLPS/Colipase antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the CLPS Antibody / Pancreatic Digestive Enzyme Marker should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: CLPS/Colipase antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for CLPS

Target: CLPS (Colipase, Pancreatic (CLPS))

Alternative Name: CLPS

Background: Colipase (CLPS) is a pancreatic secreted protein that functions as an essential cofactor for pancreatic lipase, enabling efficient digestion of dietary lipids in the small intestine. CLPS Antibody is widely used to study this protein in pancreatic tissue and digestive systems, where it is produced by acinar cells and secreted into the gastrointestinal tract to support lipid hydrolysis and nutrient absorption.

The CLPS Antibody / Pancreatic Digestive Enzyme Marker is designed to detect Colipase in pathways associated with exocrine pancreatic function and digestive enzyme activity. CLPS antibody, also referred to as Colipase antibody or pancreatic colipase antibody in the literature, enables identification of this protein in tissue and lysate-based assays where characterization of digestive enzyme systems is required. Its restricted expression in pancreatic acinar cells makes it a highly specific marker of exocrine pancreas biology.

Functionally, Colipase binds pancreatic lipase and facilitates its interaction with lipid substrates in the presence of bile salts, stabilizing the enzyme at the lipid-water interface. This interaction is critical for efficient triglyceride breakdown and absorption of fatty acids. CLPS Antibody is therefore valuable for studying digestive physiology, enzyme regulation, and pancreatic exocrine function in both normal and disease contexts.

CLPS is primarily expressed in pancreatic acinar cells, where it is synthesized, processed, and secreted into the digestive tract. In immunohistochemistry, this is reflected by strong cytoplasmic staining in acinar structures, consistent with protein production and secretion. Minimal expression is typically observed in non-pancreatic tissues, reinforcing its specificity as a pancreatic marker.

Subcellularly, Colipase is synthesized in the endoplasmic reticulum and processed through the secretory pathway prior to release. In western blot analysis, CLPS is detected as a relatively low molecular weight protein consistent with its mature secreted form. Detection across pancreatic and related tissue lysates provides insight into protein expression levels and secretion dynamics.

This CLPS Antibody is supported by western blot data demonstrating detection of Colipase in relevant tissue lysates, along with immunohistochemistry data showing strong staining in pancreatic tissue consistent with known expression patterns. Together, these features support its use in studies of digestive enzyme biology, pancreatic function, and lipid metabolism.

This antibody is part of a < a href=../antibodies.php>broader antibody panel offered by NSJ Bioreagents.

UniProt: P04118

Pathways: Lipid Metabolism