Recombinant Cytomegalovirus (CMV) (C-Term) antibody

Catalog No. ABIN8093122

This Mouse Monoclonal antibody specifically detects Cytomegalovirus in IHC. It exhibits reactivity toward Human Herpesvirus 5 (HHV-5).

Quick Overview for Recombinant Cytomegalovirus (CMV) (C-Term) antibody (ABIN8093122)

Target: Cytomegalovirus (CMV)

Antibody Type: Recombinant Antibody

Reactivity: Human Herpesvirus 5 (HHV-5)

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: RCMV-12688

Product Details

Binding Specificity: C-Term

Purpose: Cytomegalovirus Antibody / UL83 / CMV matrix protein pp65 (azide and preservative free)

Immunogen: Prokaryotic recombinant protein corresponding to a region at the C-terminal end of the cytomegalovirus pp65 molecule was used as the immunogen for the Phosphoprotein 65/UL83 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: 1. Optimal dilution of the Phosphoprotein 65/UL83 antibody should be determined by the researcher.

2. This Phosphoprotein 65/UL83 antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage Comment: Phosphoprotein 65/UL83 antibody with sodium azide - store at 2 to 8oC

Target Details

Target: Cytomegalovirus (CMV)

Alternative Name: Cytomegalovirus

Target Type: Virus

Background: Phosphoprotein 65 antibody recognizes UL83, also known as pp65, Human cytomegalovirus phosphoprotein 65, and Major Tegument Protein, a highly abundant structural component of Human cytomegalovirus virions. Phosphoprotein 65 Antibody targets one of the most immunodominant viral proteins expressed during active HCMV infection and packaged within the viral tegument layer. As the UL83 gene product, pp65 serves as both a structural virion protein and a regulator of host immune responses.

The UL83 gene encodes a lower matrix phosphoprotein that localizes primarily to the cytoplasm of infected cells, with early nuclear trafficking observed shortly after viral entry. As a tegument-associated protein, pp65 is delivered into host cells during infection and participates in modulation of innate immune signaling pathways, including interference with interferon-mediated antiviral responses. This activity contributes to viral immune evasion and supports efficient viral replication.

Phosphoprotein 65 is abundantly expressed during lytic infection and is widely used as a biomarker for active cytomegalovirus replication in research applications. Because of its strong immunogenicity, pp65 is a dominant antigen recognized by cytotoxic T lymphocytes in infected individuals. Its high expression levels and structural role in virion assembly make UL83 a preferred target for detection of HCMV-infected cells in experimental systems studying viral pathogenesis and host-virus interactions.

The UL83 protein is conserved across clinical HCMV isolates and remains central to investigations of transplant-associated CMV reactivation, congenital infection, and viral persistence in immunocompromised populations. Detection of pp65 expression assists in characterizing infection dynamics and evaluating antiviral strategies in laboratory models.

Clone rCMV/12688 is a recombinant mouse monoclonal antibody that recognizes UL83 / Phosphoprotein 65 and supports research applications focused on cytomegalovirus detection, viral replication studies, and immune response characterization.

UniProt: P06725