Recombinant DDX17 antibody

Catalog No. ABIN8093126

The Rabbit Monoclonal anti-DDX17 antibody is suitable to detect DDX17 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for Recombinant DDX17 antibody (ABIN8093126)

Target: DDX17 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 (DDX17))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This DDX17 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 23D15

Product Details anti-DDX17 Antibody

Purpose: DDX17 Antibody / DEAD-box helicase 17

Purification: Affinity chromatography

Immunogen: A synthesized peptide derived from human DEAD-box helicase 17 protein was used as the immunogen for the DDX17 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DDX17 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the DDX17 antibody at -20oC.

Target Details for DDX17

Target: DDX17 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 (DDX17))

Alternative Name: DDX17

Background: DDX17 antibody targets DEAD-box helicase 17 (DDX17), a member of the DEAD-box RNA helicase family that plays a central role in RNA metabolism and gene expression regulation. DDX17 is predominantly localized to the nucleus, where it associates with chromatin and RNA-processing complexes, although cytoplasmic distribution has also been reported under certain cellular conditions. As an ATP-dependent RNA helicase, DDX17 participates in remodeling RNA secondary structures, a fundamental process required for efficient transcription, splicing, and RNA maturation. This functional versatility places DDX17 at the core of post-transcriptional regulatory networks.

Functionally, DDX17 is best characterized for its involvement in pre-mRNA splicing and transcriptional regulation. It acts as a co-regulator by interacting with transcription factors, RNA polymerase II, and components of the spliceosome, thereby influencing exon selection and transcript diversity. DDX17 can modulate alternative splicing events that are critical for cell-type specific gene expression programs. Through these activities, DDX17 contributes to the fine-tuning of gene expression in response to developmental cues and signaling pathways. A DDX17 antibody supports studies focused on RNA processing and transcriptional control mechanisms.

DDX17 is widely expressed across tissues and cell types, reflecting its essential role in fundamental cellular processes. Its expression and activity are dynamically regulated during differentiation and in response to cellular stress. DDX17 often functions in concert with closely related RNA helicases, forming regulatory complexes that integrate transcriptional and post-transcriptional control. Analysis of DDX17 expression patterns can provide insight into how RNA helicase activity contributes to cellular plasticity and adaptive gene regulation.

From a biological and disease-relevance perspective, DDX17 has been implicated in development, cancer biology, and cellular stress responses. Dysregulation of DDX17 expression or function has been associated with altered splicing patterns and transcriptional programs that may contribute to tumor progression and metastasis. DDX17 has also been linked to pathways governing cell proliferation and differentiation, making it an important target for studies investigating RNA-based regulatory mechanisms in disease contexts. Understanding how DDX17 integrates RNA helicase activity with transcriptional control remains an active area of research.

At the molecular level, the DDX17 gene encodes a protein of approximately 72 kDa containing conserved DEAD-box motifs required for ATP binding and helicase activity. These motifs enable DDX17 to unwind RNA structures and facilitate RNA-protein interactions within regulatory complexes. Proper DDX17 function depends on coordinated interactions with RNA substrates and partner proteins. A DDX17 antibody enables detection and analysis of DDX17 expression in diverse experimental systems, supporting research into RNA biology, gene regulation, and disease-associated transcriptional dysregulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q92841

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Muscle Cell Differentiation