ELF2 antibody (C-Term)

Catalog No. ABIN8093136

The Rabbit Polyclonal anti-ELF2 antibody (ABIN8093136) specifically detects ELF2 in WB and FACS. The antibody is reactive with Human samples.

Quick Overview for ELF2 antibody (C-Term) (ABIN8093136)

Target: ELF2 (E74-Like Factor 2 (Ets Domain Transcription Factor) (ELF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ELF2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-ELF2 Antibody

Binding Specificity: C-Term

Purpose: ELF2 Antibody / E74-like ETS transcription factor 2

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human E74-like ETS transcription factor 2 was used as the immunogen for the ELF2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ELF2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ELF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ELF2

Target: ELF2 (E74-Like Factor 2 (Ets Domain Transcription Factor) (ELF2))

Alternative Name: ELF2

Background: ELF2 antibody targets E74-like ETS transcription factor 2, encoded by the ELF2 gene. E74-like ETS transcription factor 2 is a nuclear transcription factor belonging to the ETS family, which is defined by a conserved ETS DNA-binding domain that recognizes purine-rich promoter elements. Members of this family regulate gene expression programs involved in cell differentiation, proliferation, and lineage-specific development.

Functionally, E74-like ETS transcription factor 2 acts as a transcriptional regulator by binding to ETS-responsive elements within target gene promoters. ELF2 has been shown to modulate transcriptional networks involved in hematopoietic cell function, immune signaling, and epithelial cell regulation. An ELF2 antibody supports studies focused on transcriptional control mechanisms and ETS family-mediated gene regulation.

ELF2 expression has been reported in multiple tissue types, with notable roles in immune-related cells and epithelial contexts. Subcellular localization is predominantly nuclear, consistent with its function as a transcription factor, although distribution can vary depending on cellular state and regulatory signaling. Changes in ELF2 expression or activity may influence downstream transcriptional programs rather than immediate enzymatic outputs.

From a disease-relevance perspective, altered ELF2 expression has been investigated in cancer and immune-associated conditions, where dysregulated transcription factor activity can contribute to abnormal cell growth or altered differentiation states. At the molecular level, E74-like ETS transcription factor 2 contains a conserved ETS domain and regulatory regions that mediate DNA binding and protein-protein interactions. ELF2 antibody reagents support research applications focused on transcriptional regulation and nuclear signaling pathways, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q15723