EGFL7 antibody (AA 1-200)

Catalog No. ABIN8093142

The Mouse Monoclonal anti-EGFL7 antibody (Clone EGFL7-9499) (ABIN8093142) specifically detects EGFL7 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for EGFL7 antibody (AA 1-200) (ABIN8093142)

Target: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EGFL7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: EGFL7-9499

Product Details anti-EGFL7 Antibody

Binding Specificity: AA 1-200

Purpose: EGFL7 Antibody / EGF-like domain-containing protein 7

Immunogen: A recombinant fragment (around amino acids 1-200) of human EGFL7 protein (exact sequence is proprietary) was used as the immunogen for the Epidermal Growth Factor-Like Protein 7/EGFL7 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Epidermal Growth Factor-Like Protein 7/EGFL7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Epidermal Growth Factor-Like Protein 7/EGFL7 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for EGFL7

Target: EGFL7 (EGF-Like-Domain, Multiple 7 (EGFL7))

Alternative Name: EGFL7

Background: Epidermal Growth Factor-Like Protein 7 antibody, also known as EGFL7 antibody, recognizes a secreted extracellular matrix-associated protein commonly referred to as EGF-like domain-containing protein 7 and Vascular endothelial statin. Epidermal Growth Factor-Like Protein 7 is encoded by the EGFL7 gene located on chromosome 9q34 and is predominantly expressed by endothelial cells. The protein is secreted into the extracellular space, where it incorporates into the vascular basement membrane and contributes to vascular integrity and remodeling. EGFL7 expression is particularly elevated during embryonic angiogenesis and in tissues undergoing active vascular remodeling.

Epidermal Growth Factor-Like Protein 7 functions as a regulator of endothelial cell adhesion, migration, and tubule formation. It plays a key role in vascular lumen formation and stabilization of endothelial architecture. EGFL7 antibody is widely used in studies of angiogenesis, tumor-associated neovascularization, and vascular development. The protein has also been shown to modulate Notch signaling in endothelial cells, influencing vascular patterning and differentiation during development.

Structurally, Epidermal Growth Factor-Like Protein 7 contains multiple epidermal growth factor-like repeats that mediate interactions with integrins and other extracellular matrix components. Through these domains, EGFL7 supports endothelial cell-matrix communication and maintains vascular stability. Its expression is developmentally regulated, with high levels in embryonic vasculature and more restricted expression in adult tissues except during repair, inflammation, or tumor angiogenesis.

Dysregulated EGFL7 expression has been associated with cancer progression and metastasis. Increased EGFL7 levels are observed in colorectal, breast, and hepatocellular carcinomas, where enhanced angiogenesis supports tumor growth and dissemination. Because EGFL7 is largely endothelial-specific, it serves as a valuable marker for studying tumor vasculature and vascular remodeling processes. Its extracellular localization also makes it of interest in therapeutic strategies targeting angiogenesis.

Epidermal Growth Factor-Like Protein 7 antibody supports research in vascular biology, angiogenesis, and tumor microenvironment signaling. Clone EGFL7/9499 recognizes EGFL7 and is suitable for detecting Epidermal Growth Factor-Like Protein 7 expression in relevant research applications.

UniProt: Q9UHF1