ERG antibody (AA 1-300)

Catalog No. ABIN8093153

The Mouse Monoclonal anti-ERG antibody is suitable to detect ERG in samples from Human. It has been validated for IHC.

Quick Overview for ERG antibody (AA 1-300) (ABIN8093153)

Target: ERG (ERG, ETS transcription factor (ERG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERG antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: ERG1-12590

Product Details anti-ERG Antibody

Binding Specificity: AA 1-300

Purpose: ERG Antibody / ETS related gene

Immunogen: A recombinant fragment (around amino acids 1-300) of human ERG (exact sequence is proprietary) was used as the immunogen for the ERG/ETS related gene antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the ERG/ETS related gene antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: ERG/ETS related gene antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for ERG

Target: ERG (ERG, ETS transcription factor (ERG))

Alternative Name: ERG

Background: ERG antibody targets ETS related gene, a nuclear transcription factor encoded by the ERG gene and a member of the ETS family of transcriptional regulators. ERG plays a critical role in gene expression programs that control endothelial cell differentiation, vascular development, and hematopoietic lineage specification. Through sequence-specific DNA binding, ERG regulates transcriptional networks essential for cell identity and tissue homeostasis.

ERG is predominantly localized in the nucleus and is highly expressed in vascular endothelial cells and cells of hematopoietic origin. Its expression pattern makes ERG antibody detection particularly useful for identifying endothelial cells and assessing vascular differentiation in tissue samples. In addition, ERG expression is observed in subsets of hematologic cells, reflecting its role in blood cell development and maintenance.

Functionally, ERG regulates genes involved in cell survival, migration, and differentiation. In endothelial cells, ERG supports vascular stability and angiogenic capacity by modulating transcriptional responses to developmental and environmental cues. ERG antibody reagents therefore support investigations into transcriptional control mechanisms underlying vascular biology and endothelial cell function.

Alterations in ERG expression are associated with several disease contexts. ERG gene rearrangements and overexpression are well documented in prostate cancer, most commonly through fusion with androgen-regulated promoters, leading to aberrant transcriptional activity. ERG expression has also been implicated in certain leukemias and vascular tumors, where dysregulated transcription contributes to disease progression. These associations highlight the relevance of ERG antibody-based detection in cancer research and hematopathology studies.

Clone ERG1/12590 is designed to recognize ETS related gene in research applications. ERG antibody reagents are suitable for detecting nuclear ERG expression in endothelial and hematopoietic cells, supporting studies focused on vascular biology, transcriptional regulation, and disease-associated alterations in ETS family signaling.

UniProt: P11308