Recombinant ERG antibody (AA 1-300)

Catalog No. ABIN8093158

This Rabbit Monoclonal antibody specifically detects ERG in ELISA. It exhibits reactivity toward Human.

Quick Overview for Recombinant ERG antibody (AA 1-300) (ABIN8093158)

Target: ERG (ERG, ETS transcription factor (ERG))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ERG antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: ERG-9604R

Product Details anti-ERG Antibody

Binding Specificity: AA 1-300

Purpose: ERG Antibody / Erythroblast transformation specific related gene (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1-300) of human ERG protein (exact sequence is proprietary) was used as the immunogen for the ERG/ERG transcription factor antibody.

Isotype: IgG, kappa

Application Details

Application Notes: 1. Optimal dilution of the ERG/ERG transcription factor antibody should be determined by the researcher.

2. This ERG/ERG transcription factor antibody is recombinantly produced by expression in CHO cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: ERG/ERG transcription factor antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for ERG

Target: ERG (ERG, ETS transcription factor (ERG))

Alternative Name: ERG

Background: ERG antibody targets ERG transcription factor, a nuclear DNA-binding protein encoded by the ERG gene and a member of the ETS family of transcription factors. ERG functions as a sequence-specific regulator of gene expression and plays a central role in controlling cellular differentiation programs, lineage commitment, and maintenance of cell identity. Through transcriptional regulation, ERG influences diverse biological processes across vascular, hematopoietic, and developmental systems.

ERG transcription factor is localized to the nucleus, where it binds ETS consensus motifs within promoter and enhancer regions of target genes. Its activity is tightly regulated during development and in adult tissues, reflecting its importance in maintaining stable transcriptional states. ERG antibody detection is therefore useful for studying nuclear transcription factor expression and transcriptional network regulation in tissue-based and cell-based research models.

Functionally, ERG controls genes involved in cell survival, proliferation, and differentiation. In hematopoietic and progenitor cell populations, ERG supports lineage specification and self-renewal, while in endothelial and mesenchymal contexts it contributes to transcriptional programs governing structural and functional specialization. ERG antibody reagents support investigations into how transcription factors coordinate complex gene expression patterns underlying tissue development and homeostasis.

Dysregulation of ERG transcriptional activity has been implicated in multiple disease processes. Aberrant ERG expression or activation alters downstream gene networks and can contribute to pathological cell states, including malignant transformation and impaired differentiation. These transcriptional changes highlight the relevance of ERG antibody-based detection for research into disease-associated gene regulation and transcription factor dysfunction.

Clone ERG/9604R is designed to recognize ERG transcription factor in research applications. ERG antibody reagents are suitable for detecting nuclear ERG expression in diverse tissue types, supporting studies focused on transcriptional regulation, cell lineage biology, and disease-associated alterations in gene expression control.

UniProt: P11308