HSD17B13 antibody (AA 1-200)

Catalog No. ABIN8093249

The Mouse Monoclonal anti-HSD17B13 antibody is suitable to detect HSD17B13 in samples from Human. It has been validated for WB and IHC.

Quick Overview for HSD17B13 antibody (AA 1-200) (ABIN8093249)

Target: HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSD17B13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: HSD17B13-13105

Product Details anti-HSD17B13 Antibody

Binding Specificity: AA 1-200

Purpose: HSD17B13 Antibody / Hydroxysteroid 17 beta dehydrogenase 13 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1-200) of human HSD17B13 protein (exact sequence is proprietary) was used as the immunogen for the HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: HSD17B13/Hydroxysteroid 17 beta dehydrogenase 13 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for HSD17B13

Target: HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13 (HSD17B13))

Alternative Name: HSD17B13

Background: HSD17B13 antibody targets Hydroxysteroid 17 beta dehydrogenase 13, a liver-enriched enzyme encoded by the HSD17B13 gene that belongs to the hydroxysteroid dehydrogenase family. Hydroxysteroid 17 beta dehydrogenase 13 is predominantly localized to the cytoplasm and lipid droplet-associated compartments of hepatocytes, where it participates in hepatic lipid metabolism and steroid-related redox processes. Because of its strong liver specificity, an HSD17B13 antibody is widely used in studies of liver biology and metabolic disease.

Hydroxysteroid 17 beta dehydrogenase 13 is structurally related to other 17 beta-hydroxysteroid dehydrogenases but displays distinct substrate specificity and tissue distribution. It contains a conserved short-chain dehydrogenase reductase domain, supporting enzymatic activity linked to lipid and steroid metabolism. In hepatocytes, HSD17B13 associates with lipid droplets and is thought to modulate lipid storage and turnover, making antibody-based detection valuable for investigating hepatocellular metabolic regulation.

Genetic studies have identified HSD17B13 as a key modifier of liver disease risk. Specific loss-of-function variants in the HSD17B13 gene are associated with protection against non-alcoholic fatty liver disease, steatohepatitis, and progression to cirrhosis. Conversely, altered expression of Hydroxysteroid 17 beta dehydrogenase 13 has been reported in fatty liver disease and hepatocellular carcinoma. Use of an HSD17B13 antibody enables analysis of protein expression patterns linked to liver pathology and disease susceptibility.

Hydroxysteroid 17 beta dehydrogenase 13 expression is largely restricted to liver tissue, with minimal expression detected in most extrahepatic tissues. This restricted distribution makes HSD17B13 a useful marker for hepatocyte identity and liver-specific metabolic states. An HSD17B13 antibody can therefore support studies of hepatic differentiation, liver injury, and metabolic remodeling.

Clone HSD17B13/13105 is designed to recognize Hydroxysteroid 17 beta dehydrogenase 13 and supports detection of HSD17B13 expression in research applications. NSJ Bioreagents offers this HSD17B13 antibody to support investigations into liver metabolism, fatty liver disease, and hepatocellular biology.

UniProt: Q7Z5P4