CDH6 antibody (AA 250-450)

Catalog No. ABIN8093275

This Mouse Monoclonal antibody specifically detects CDH6 in IHC. It exhibits reactivity toward Human.

Quick Overview for CDH6 antibody (AA 250-450) (ABIN8093275)

Target: CDH6 (K-Cadherin (CDH6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDH6 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: CDH6-9347

Product Details anti-CDH6 Antibody

Binding Specificity: AA 250-450

Purpose: CDH6 Antibody / Cadherin 6 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 250-450) of human Cadherin 6 protein (CDH6) (exact sequence is proprietary) was used as the immunogen for the CDH6/Cadherin 6 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CDH6/Cadherin 6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: CDH6/Cadherin 6 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for CDH6

Target: CDH6 (K-Cadherin (CDH6))

Alternative Name: CDH6

Background: CDH6 antibody targets Cadherin 6, also known as K-Cadherin, a calcium-dependent cell-cell adhesion molecule encoded by the CDH6 gene and a member of the classical cadherin family. Cadherin 6 is a single-pass transmembrane glycoprotein predominantly localized to the plasma membrane at adherens junctions, where it mediates homophilic adhesion between neighboring cells. CDH6 expression is most prominent in renal epithelium, nervous system tissues, and select epithelial compartments, reflecting its role in tissue organization and morphogenesis.

Functionally, Cadherin 6 contributes to epithelial cohesion and structural integrity by linking adjacent cells through calcium-dependent interactions and coupling to the actin cytoskeleton via catenin complexes. A short functional summary is that CDH6 supports stable cell-cell adhesion required for proper epithelial architecture and differentiation. Through these adhesive functions, K-Cadherin influences cell polarity, migration, and tissue patterning during development.

At the molecular level, Cadherin 6 contains multiple extracellular cadherin repeat domains responsible for calcium binding and adhesive specificity, a transmembrane region, and a conserved cytoplasmic tail that interacts with beta-catenin and related adaptor proteins. These structural features integrate extracellular adhesion with intracellular signaling pathways. CDH6 antibody reagents are therefore valuable for studying adherens junction biology, epithelial development, and regulation of cell-cell contacts. Clone CDH6/9347 is designed to recognize Cadherin 6 and supports consistent detection of CDH6 expression in research applications.

From a biological and disease relevance perspective, altered Cadherin 6 expression has been reported in several cancers, including renal, ovarian, and thyroid carcinomas, where changes in CDH6 levels may be associated with tumor progression and invasive behavior. Cadherin 6 is also investigated in developmental biology due to its regulated expression during organogenesis. Clone CDH6/9347 provides a reliable reagent for examining Cadherin 6 expression in studies of epithelial differentiation, cancer biology, and cell adhesion dynamics.

Developmentally, CDH6 expression is tightly regulated and contributes to tissue-specific patterning and morphogenetic processes. CDH6 antibodies from NSJ Bioreagents are supplied for research use to support investigations in epithelial biology, development, and translational research.

UniProt: P55285

Pathways: Cell-Cell Junction Organization