PAX8 antibody (AA 50-300)

Catalog No. ABIN8093380

This Mouse Monoclonal antibody specifically detects PAX8 in IHC. It exhibits reactivity toward Human.

Quick Overview for PAX8 antibody (AA 50-300) (ABIN8093380)

Target: PAX8 (Paired Box 8 (PAX8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX8 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PAX8-12570

Product Details anti-PAX8 Antibody

Binding Specificity: AA 50-300

Purpose: PAX8 Antibody / Paired box protein Pax-8

Immunogen: A recombinant fragment (around amino acids 50-300) of human PAX8 protein (exact sequence is proprietary) was used as the immunogen for the Thyroid Transcription Factor PAX8 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Thyroid Transcription Factor PAX8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Thyroid Transcription Factor PAX8 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for PAX8

Target: PAX8 (Paired Box 8 (PAX8))

Alternative Name: PAX8

Background: Paired box protein Pax-8 (PAX8) is a nuclear transcription factor encoded by the PAX8 gene that plays a central role in regulating thyroid-specific gene expression and maintaining follicular epithelial cell identity. As a member of the paired box (PAX) family, PAX8 functions as a key transcriptional regulator controlling genes involved in thyroid hormone synthesis and epithelial differentiation. Thyroid Transcription Factor PAX8 Antibody is uniquely positioned for studies focused on transcriptional regulation within thyroid cells rather than general lineage identification.

PAX8 antibody, also known as Paired box protein Pax-8 antibody or Pax-8 nuclear transcription factor antibody, is highly associated with regulation of thyroid-specific gene expression. This Thyroid Transcription Factor PAX8 Antibody is uniquely positioned for detecting nuclear transcriptional activity within thyroid epithelial cells, enabling investigation of how gene expression programs are controlled at the transcription factor level. Unlike broader lineage marker pages, this page emphasizes gene regulation and transcriptional function within thyroid cells.

Functionally, PAX8 regulates expression of key thyroid genes including thyroglobulin and thyroid peroxidase, both essential for hormone production. It acts in coordination with other transcription factors such as NKX2.1 to establish and maintain thyroid-specific transcriptional networks. These interactions ensure proper regulation of gene expression required for thyroid physiology.

PAX8 operates within the nucleus, where it binds DNA and recruits transcriptional co-regulators to activate or repress target genes. Its activity reflects ongoing transcriptional control rather than simply presence of a lineage marker, making it particularly valuable for studies of gene regulation, transcriptional activation, and nuclear protein function.

The mouse monoclonal antibody clone PAX8/12570 provides a consistent and reproducible tool for detecting nuclear PAX8. As a monoclonal reagent, it supports precise identification of transcription factor localization and enables comparative analysis across experimental conditions where transcriptional activity may vary.

Thyroid Transcription Factor PAX8 Antibody therefore provides a focused approach to studying transcriptional regulation in thyroid epithelial cells. Its emphasis on nuclear function, gene regulation, and transcription factor activity differentiates it from general PAX8 lineage markers, making it particularly valuable for research into thyroid gene expression, transcriptional control mechanisms, and epithelial cell regulation.

UniProt: Q06710

Pathways: Thyroid Hormone Synthesis, Regulation of Hormone Metabolic Process, Stem Cell Maintenance, Tube Formation