Recombinant PVALB antibody (full length)

Catalog No. ABIN8093394

The Rabbit Monoclonal anti-PVALB antibody (Clone PVALB-12610R) (ABIN8093394) specifically detects PVALB in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant PVALB antibody (full length) (ABIN8093394)

Target: PVALB (Parvalbumin (PVALB))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PVALB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: PVALB-12610R

Product Details anti-PVALB Antibody

Binding Specificity: full length

Purpose: PVALB Antibody / Parvalbumin (azide and preservative free)

Immunogen: Recombinant full-length human PVALB protein was used as the immunogen for the Fast-Spiking Interneuron Marker/Parvalbumin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Fast-Spiking Interneuron Marker/Parvalbumin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Fast-Spiking Interneuron Marker/Parvalbumin antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for PVALB

Target: PVALB (Parvalbumin (PVALB))

Alternative Name: PVALB

Background: Fast-Spiking Interneuron Marker antibody, also known as Parvalbumin antibody, recognizes Parvalbumin, a small cytosolic EF-hand calcium-binding protein encoded by the human PVALB gene on chromosome 22q12.3. Commonly referred to as Parvalbumin or PV in the neuroscience literature, this protein is predominantly localized to the cytoplasm and is highly expressed in fast-spiking GABAergic interneurons of the cerebral cortex, hippocampus, and cerebellum. It is also present in fast-twitch skeletal muscle fibers. Fast-Spiking Interneuron Marker antibody is widely used to identify interneuron subpopulations that regulate cortical excitability and synchronize neuronal network activity.

Parvalbumin functions primarily as an intracellular calcium buffer. Structurally, it contains three EF-hand motifs, two of which are functional calcium-binding domains capable of binding calcium with high affinity. This buffering capacity allows rapid sequestration of calcium following action potentials, supporting high-frequency firing and precise synaptic timing in inhibitory interneurons. In skeletal muscle, Parvalbumin accelerates relaxation after contraction, particularly in glycolytic fast-twitch fibers. During postnatal brain development, Parvalbumin expression increases as inhibitory circuits mature and gamma oscillatory activity becomes established.

Within the central nervous system, Parvalbumin-positive interneurons often co-localize with synaptic proteins involved in vesicle release and cytoskeletal organization, reflecting their specialization for rapid neurotransmission. Disruption of Parvalbumin-expressing interneurons has been associated with neurological and psychiatric conditions including epilepsy, schizophrenia, and autism spectrum disorders, where altered inhibitory tone and impaired network synchronization are implicated. In muscle biology, Parvalbumin expression correlates with fiber type specification and metabolic properties.

Fast-Spiking Interneuron Marker antibody is suitable for detecting Parvalbumin expression in studies of neural circuitry, neurodevelopment, and muscle physiology. Recombinant monoclonal clone PVALB/12610R is produced using defined expression systems to promote lot-to-lot consistency and reliable performance. A Parvalbumin antibody such as clone PVALB/12610R supports research focused on inhibitory interneuron identification and calcium-buffering protein analysis.

UniProt: P20472