PDE8B antibody (C-Term)

Catalog No. ABIN8093408

The Rabbit Polyclonal anti-PDE8B antibody is suitable to detect PDE8B in samples from Human. It has been validated for WB and IF.

Quick Overview for PDE8B antibody (C-Term) (ABIN8093408)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE8B antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PDE8B Antibody

Binding Specificity: C-Term

Purpose: PDE8B Antibody / Phosphodiesterase 8B

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Phosphodiesterase 8B was used as the immunogen for the PDE8B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PDE8B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PDE8B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Alternative Name: PDE8B

Background: PDE8B antibody targets Phosphodiesterase 8B, encoded by the PDE8B gene. Phosphodiesterase 8B is a cytoplasmic enzyme that belongs to the phosphodiesterase family of cyclic nucleotide hydrolases and is highly selective for cyclic AMP. By catalyzing the hydrolysis of cAMP to AMP, PDE8B plays an important role in regulating intracellular second messenger signaling and maintaining precise control of cAMP-dependent pathways.

Phosphodiesterase 8B is distinguished from many other PDE family members by its high affinity for cAMP and its relative insensitivity to common non-selective phosphodiesterase inhibitors. This biochemical profile allows PDE8B to fine-tune localized cAMP pools rather than broadly suppress cyclic nucleotide signaling. A PDE8B antibody supports studies focused on cAMP metabolism, signal compartmentalization, and regulation of protein kinase A dependent pathways.

PDE8B expression has been reported in multiple tissues, with notable roles in endocrine and metabolic contexts where tight regulation of cAMP signaling is essential. At the subcellular level, Phosphodiesterase 8B is primarily localized to the cytoplasm, where it can modulate signaling complexes that depend on rapid changes in cyclic nucleotide concentration. Its expression pattern and localization support a role in shaping stimulus-specific cAMP responses rather than global signaling shutdown.

From a disease-related perspective, altered PDE8B activity has been investigated in disorders involving dysregulated cAMP signaling, including endocrine abnormalities and certain cancers. Genetic variation or changes in PDE8B expression can influence hormone responsiveness and downstream transcriptional programs, highlighting its relevance in studies of signaling imbalance and cellular regulation.

At the molecular level, Phosphodiesterase 8B contains conserved catalytic domains characteristic of cAMP-specific phosphodiesterases, supporting efficient cyclic nucleotide hydrolysis. Its activity and apparent behavior in experimental systems may vary with cellular context and signaling state without altering the underlying protein structure. PDE8B antibody reagents enable investigation of cAMP signaling regulation and phosphodiesterase biology, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q9BRX2

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process