PVRL4 antibody (AA 1-200)

Catalog No. ABIN8093417

The Mouse Monoclonal anti-PVRL4 antibody is suitable to detect PVRL4 in samples from Human. It has been validated for WB and IHC.

Quick Overview for PVRL4 antibody (AA 1-200) (ABIN8093417)

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVRL4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: NECTIN4-9906

Product Details anti-PVRL4 Antibody

Binding Specificity: AA 1-200

Purpose: NECTIN4 Antibody / Nectin cell adhesion molecule 4 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1-200) of human NECTIN4 protein (exact sequence is proprietary) was used as the immunogen for the Nectin cell adhesion molecule 4/NECTIN4 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Nectin cell adhesion molecule 4/NECTIN4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Nectin cell adhesion molecule 4/NECTIN4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for PVRL4

Target: PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))

Alternative Name: NECTIN4

Background: Nectin cell adhesion molecule 4 antibody, also known as NECTIN4 antibody, recognizes Nectin cell adhesion molecule 4, a type I transmembrane glycoprotein encoded by the NECTIN4 gene. Commonly referred to as Nectin-4 and also known as Poliovirus receptor related 4 (PVRL4), this protein is a member of the nectin family within the immunoglobulin superfamily. NECTIN4 localizes primarily to the plasma membrane at adherens junctions, where it mediates Ca2+-independent cell-cell adhesion and contributes to epithelial tissue integrity. Nectin cell adhesion molecule 4 antibody is widely used in studies of epithelial organization, cell polarity, and tumor-associated membrane protein expression.

NECTIN4 contains three extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail that interacts with intracellular adaptor proteins involved in junction assembly and cytoskeletal linkage. Through homophilic and heterophilic interactions with other nectin family members, Nectin cell adhesion molecule 4 regulates adhesion strength, cell sorting, and tissue morphogenesis. In normal tissues, expression is relatively restricted, with detectable levels in skin, placenta, and select epithelial compartments. During development, nectin family proteins play roles in coordinated cell positioning and junctional maturation.

Overexpression of NECTIN4 has been reported in several epithelial malignancies, including urothelial carcinoma, breast cancer, lung cancer, and ovarian cancer. Elevated membrane expression has been associated with enhanced proliferation and tumor progression, supporting its relevance as a biomarker in oncology research. Immunostaining typically demonstrates membranous localization in positive tumor cells, consistent with its function as a cell surface adhesion molecule. Clone NECTIN4/9906 is designed to detect Nectin cell adhesion molecule 4 in research applications and supports investigation of epithelial adhesion dynamics, tumor biology, and membrane-associated signaling pathways.

UniProt: Q96NY8

Pathways: Cell-Cell Junction Organization