SALL4 antibody (AA 200-500)

Catalog No. ABIN8093450

The Mouse Monoclonal anti-SALL4 antibody is suitable to detect SALL4 in samples from Human. It has been validated for IHC.

Quick Overview for SALL4 antibody (AA 200-500) (ABIN8093450)

Target: SALL4 (Sal-Like 4 (SALL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SALL4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: SALL4-12615

Product Details anti-SALL4 Antibody

Binding Specificity: AA 200-500

Purpose: SALL4 Antibody / Sal-like protein 4

Immunogen: A recombinant fragment (around amino acids 200-500) of human SALL-4 protein (exact sequence is proprietary) was used as the immunogen for the ZNF797/Spalt-like Transcription Factor 4 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the ZNF797/Spalt-like Transcription Factor 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: ZNF797/Spalt-like Transcription Factor 4 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for SALL4

Target: SALL4 (Sal-Like 4 (SALL4))

Alternative Name: SALL4

Background: ZNF797 antibody, also known as Spalt-like transcription factor 4 antibody, recognizes a zinc finger transcription factor encoded by the SALL4 gene that plays a critical role in embryonic development, stem cell pluripotency, and lineage specification. ZNF797 is a member of the Spalt-like family of C2H2 zinc finger proteins and functions primarily as a nuclear transcriptional regulator. It contains multiple zinc finger domains that mediate DNA binding as well as transcriptional repression or activation through recruitment of chromatin remodeling complexes. High expression of ZNF797 is observed in embryonic stem cells, germ cells, and early developmental tissues, where it supports maintenance of an undifferentiated state and regulates genes involved in proliferation and differentiation. In adult tissues, expression is more restricted but can be detected in select progenitor cell populations.

Spalt-like transcription factor 4 has been widely studied in the context of oncogenesis. Aberrant re-expression of ZNF797 in somatic tissues is associated with multiple malignancies, including germ cell tumors, hepatocellular carcinoma, acute myeloid leukemia, and other aggressive neoplasms. Its role in tumor biology is linked to promotion of proliferation, inhibition of differentiation, and interaction with epigenetic regulatory complexes such as NuRD. ZNF797 can act downstream of key pluripotency networks and is functionally connected with transcription factors including OCT4 and NANOG, reinforcing stem-like characteristics in cancer cells. Due to this biology, ZNF797 is frequently used as a diagnostic and research marker for germ cell tumors and stem cell related cancers.

The ZNF797 antibody is suitable for detecting nuclear expression patterns consistent with its function as a transcriptional regulator. In immunohistochemistry applications, positive staining is typically nuclear within germ cells, embryonal carcinoma components, or tumor cells with stem-like features. The recombinant monoclonal clone SALL4/12615 is designed to provide specific recognition of Spalt-like transcription factor 4 in research applications. Detection of ZNF797 expression can support studies of developmental biology, stem cell maintenance, epigenetic regulation, and tumor progression mechanisms.

UniProt: Q9UJQ4

Pathways: Stem Cell Maintenance, Tube Formation