Recombinant SATB2 antibody (AA 1-200)

Catalog No. ABIN8093454

The Rabbit Monoclonal anti-SATB2 antibody (Clone SATB2-9432R) (ABIN8093454) specifically detects SATB2 in WB and IHC. The antibody is reactive with Human samples.

Quick Overview for Recombinant SATB2 antibody (AA 1-200) (ABIN8093454)

Target: SATB2 (SATB Homeobox 2 (SATB2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SATB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: SATB2-9432R

Product Details anti-SATB2 Antibody

Binding Specificity: AA 1-200

Purpose: SATB2 Antibody / DNA-binding protein SATB2

Immunogen: A recombinant fragment (around amino acids 1-200) of human SATB2 (exact sequence is proprietary) was used as the immunogen for the recombinant SATB2 Transcription Factor antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the SATB2 Transcription Factor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: SATB2 Transcription Factor antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Target Details for SATB2

Target: SATB2 (SATB Homeobox 2 (SATB2))

Alternative Name: SATB2

Background: SATB2 Transcription Factor Antibody recognizes Special AT-rich sequence-binding protein 2, a nuclear DNA-binding protein that functions as a global chromatin organizer and transcriptional regulator. SATB2 is widely known as a transcription factor involved in higher-order chromatin remodeling, where it regulates gene expression by tethering specialized DNA sequences to a chromatin network within the nucleus. SATB2 Transcription Factor Antibody is commonly used in research settings to study nuclear transcriptional regulation, chromatin organization, and lineage-specific gene expression programs in epithelial and neuronal tissues. The SATB2 protein is predominantly localized to the nucleus, consistent with its role in transcriptional control and genome architecture.

SATB2 is encoded by the SATB2 gene and is highly expressed in specific cell populations, including colorectal epithelial cells, osteoblasts, and subsets of neuronal cells during development. In adult tissues, SATB2 expression is most prominent in the lower gastrointestinal tract, particularly in colonic epithelium, making it a well-established marker of colorectal lineage. SATB2 Transcription Factor Antibody therefore plays an important role in studies focused on intestinal differentiation, epithelial identity, and tissue-specific transcriptional regulation. Clone SATB2/9432R is designed to recognize SATB2 protein and supports investigation of its nuclear expression patterns in relevant experimental models.

In cancer research, SATB2 has gained significant attention due to its diagnostic and biological relevance in colorectal cancer and related malignancies. SATB2 expression is frequently retained in tumors of colorectal origin and is used extensively as a lineage-associated marker in translational and pathology-oriented research studies. Beyond its diagnostic utility, SATB2 contributes to transcriptional programs that influence cell differentiation, proliferation, and tumor behavior. SATB2 Transcription Factor Antibody enables detailed examination of SATB2-positive nuclei, supporting research into tumor classification, molecular pathology, and transcription factor-driven oncogenic processes. Clone SATB2/9432R may be used to assess SATB2 expression in these contexts without implying clinical validation.

Outside of oncology, SATB2 also plays a critical role in developmental biology, particularly in craniofacial development, neuronal differentiation, and cortical patterning. Its function as a chromatin regulator places SATB2 at the intersection of epigenetic control and transcriptional specificity. SATB2 Transcription Factor Antibody provides a valuable tool for investigating how chromatin organization and transcription factor activity shape cell fate decisions, tissue development, and disease-associated transcriptional changes across a range of biological research applications.

Researchers investigating colorectal tumor markers, epithelial lineage determination, and chromatin-associated transcriptional regulation may also be interested in our < a href=../tds/recombinant-satb2-antibody-satb24374r-v8660>SATB2 Antibody / Colorectal and Lineage Marker page featuring validated immunohistochemistry and western blot applications for colorectal pathology research.

UniProt: Q9UPW6